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apalutamide will reduce the level or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medications which can be CYP3A4 substrates may end up in decreased exposure to these medicines.However, the waking system of modaf
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